Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1

Endoplasmic Reticulum Aminopeptidase

association between endoplasmic reticulum aminopeptidase-1 (erap-1) and susceptibility to ankylosing spondylitis in iran.

ankylosing spondylitis (as) is an inflammatory arthritis, which affects mainly spine and sacroiliac joints. according to recent studies, erap1 is the second most common candidate gene for  as susceptibility after hla-b27. the  aim of this study was to  determine the association of erap1 gene polymorphisms with as in iranian population. the study group comprised 387 iranian as patients and 316 h...

TLR-mediated secretion of endoplasmic reticulum aminopeptidase 1 from macrophages.

Macrophages play an important role in host defense under several immunological, inflammatory, and/or infectious conditions. In our previous work, we demonstrated that endoplasmic reticulum aminopeptidase 1 (ERAP1) was secreted from macrophages in response to LPS and IFN-γ, and it enhanced their phagocytic activity. In this study, we analyzed the mechanism of LPS/IFN-γ-induced ERAP1 secretion. L...

Association between endoplasmic reticulum aminopeptidase-1 (ERAP-1) and susceptibility to ankylosing spondylitis in Iran.

Ankylosing spondylitis (AS) is an inflammatory arthritis, which affects mainly spine and sacroiliac joints. According to recent studies, ERAP1 is the second most common candidate gene for AS susceptibility after HLA-B27. The aim of this study was to determine the association of ERAP1 gene polymorphisms with AS in Iranian population.The study group comprised 387 Iranian AS patients and 316 healt...

Bioinformatics analysis of genetic variants of endoplasmic reticulum aminopeptidase 1 in ankylosing spondylitis

According to the results of the first genome-wide association study of ankylosing spondylitis (AS), endoplasmic reticulum aminopeptidase 1 (ERAP1) may serve an important role. However, a number of case-control studies have not been able to replicate this result using the same genetic markers. In the present study, the role of common genetic variants of ERAP1 in AS was investigated using two-sta...